{"id":2068,"date":"2023-03-21T17:57:18","date_gmt":"2023-03-21T16:57:18","guid":{"rendered":"https:\/\/2023-neu.animalfree-research.org\/?p=2068"},"modified":"2023-03-22T13:44:37","modified_gmt":"2023-03-22T12:44:37","slug":"epiderm","status":"publish","type":"post","link":"https:\/\/animalfree-research.org\/en\/blog\/epiderm\/","title":{"rendered":"EpiDerm\u00a9"},"content":{"rendered":"

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EpiDerm\u00a9<\/h1>\n

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Manfred Liebsch erhielt 1996 eine F\u00f6rderung von Animalfree Research, um einen neuen in vitro Test f\u00fcr dermale Phototoxizit\u00e4t zu entwickeln.<\/strong><\/p>\n<\/div>\n<\/div>\n

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Phototoxizit\u00e4t, also die negative Wechselwirkung einer Substanz mit (UV) Licht, wird gelegentlich nach dem Auftragen auf die Haut beobachtet. Daher werden alle Bestandteile, die so appliziert werden (Medikamente, Salben, Kosmetika) auf diese Reaktion getestet. Die Standardtestung war der sogenannte Haut-Draize Test, der an Kaninchen vorgenommen wird. 24 Stunden vor Testbeginn wird das Fell der betreffenden Stelle geschoren, und die Testsubstanz wird bis zu 4 Stunden lang auf der Haut belassen. Die Versuchstiere werden dann einzeln fixiert und mit UV-Licht bestrahlt.<\/p>\n

Die Fl\u00e4che wird dann f\u00fcr Tage, eventuell auch f\u00fcr Wochen auf schmerzhafte Entz\u00fcndungsprozesse untersucht.<\/p>\n

Der Test wird zun\u00e4chst an einem Einzeltier durchgef\u00fchrt, sollte aber eine verd\u00e4chtige Reaktion auftreten, wird das Experiment an mehreren Tieren wiederholt.<\/p>\n

Manfred Liebsch erhielt 1996 F\u00f6rderung von Animalfree Research, um einen neuen in vitro Test f\u00fcr dermale Phototoxizit\u00e4t zu entwickeln. Es handelt sich um ein Modell menschlicher Epidermis (reconstituted human epidermis, RHE). Anders als andere Modelle nutzt dieser Ansatz ausdifferenzierte menschliche Hautzellen. Die Testsubstanz kann topisch auf EpiDerm aufgetragen und anschliessend UV-Licht ausgesetzt werden. Der Effekt auf die Zellen wird einen Tag sp\u00e4ter gemessen.<\/p>\n

Der EpiDerm\u00a9 wird von der Firma\u00a0Mattek<\/a>\u00a0kommerziell vertrieben.<\/p>\n

Die Kosmetikrichtlinie (2003\/15\/EG) verlangt die Umstellung bei der Testung von Kosmetika von in vivo auf in vitro Modelle. 2013 trat die letzte Stufe mit einem kompletten Verbot von Tierversuchen f\u00fcr Kosmetika in Kraft. Dies w\u00e4re nicht m\u00f6glich gewesen ohne valide Modelle wie EpiDerm. 2017 erschien ein Buchkapitel in\u00a0Alternatives to dermal toxicity testing\u00a0<\/em>mit dem Titel: The EpiDerm™ Phototoxicity Test (EpiDerm™ H3D-PT)
(Liebsch, M., and Kandarova, H., 2017, pp 483-503)<\/p>\n

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Publikationen<\/h2>\n

Liebsch M. (1997):\u00a0Entwicklung eines neuen in vitro Tests auf dermale Phototoxizit\u00e4t mit einem Modell menschlicher Epidermis.\u00a0<\/a>ALTEX 14: 165-174.<\/p>\n

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EpiDerm\u00a9 Manfred Liebsch erhielt 1996 eine F\u00f6rderung von Animalfree Research, um einen neuen in vitro Test f\u00fcr dermale Phototoxizit\u00e4t zu entwickeln. Phototoxizit\u00e4t, also die negative Wechselwirkung einer Substanz mit (UV) Licht, wird gelegentlich nach dem Auftragen auf die Haut beobachtet. Daher werden alle Bestandteile, die so appliziert werden (Medikamente, Salben, Kosmetika) auf diese Reaktion getestet. 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