{"id":2038,"date":"2023-03-21T17:53:06","date_gmt":"2023-03-21T16:53:06","guid":{"rendered":"https:\/\/2023-neu.animalfree-research.org\/?p=2038"},"modified":"2023-03-22T13:46:33","modified_gmt":"2023-03-22T12:46:33","slug":"alice-vitrocell-cloud","status":"publish","type":"post","link":"https:\/\/animalfree-research.org\/en\/blog\/alice-vitrocell-cloud\/","title":{"rendered":"ALICE\/ VitroCell CLOUD\u00a9"},"content":{"rendered":"

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ALICE\/ VitroCell CLOUD\u00a9<\/h1>\n

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Animalfree Research 2009 einen finanziellen Beitrag zu der Entwicklung der \u201eALICE\u201c (Air Liquid Interface Cell Exposure System geleistet. Das Ziel war eine praktikable und breit anwendbare Methode, die Tierversuche in einem breiten Spektrum von Gebieten ersetzen oder reduzieren sollte.<\/strong><\/p>\n<\/div>\n<\/div>\n

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Um die Wirkungen von kurz- oder langfristiger Inhalation bspw. Von Toxinen auf den Organismus zu erforschen, werden Tiere\u00a0 \u2013 vorwiegend Nager \u2013 verunreinigter Luft ausgesetzt. Gesunde Tiere werden in Inhalationskammern verbracht , f\u00fcr einen gewissen Zeitraum exponiert und dann auf Ver\u00e4nderungen untersucht.<\/p>\n

Um bestehende Vorerkrankungen zu simulieren, werden Toxine in die Lunge gespritzt (bspw. LPS oder Asbest) oder Teile der Lungen werden mechanisch oder durch Bestrahlung gesch\u00e4digt. Danach werden die Tiere den Substanzen ausgesetzt, die sie per Aerosol einatmen m\u00fcssen. Danach werden die Tiere get\u00f6tet und seziert.<\/p>\n

Solche Experimente k\u00f6nnen sehr belastend sein und sind mit der Situation des Menschen nicht gut vergleichbar. U.a. sind die anatomischen Gegebenheiten in Nase und Lunge sehr unterschiedlich. Die Entwicklung eines in vitro Systems als Ersatz zum Tierversuch war also h\u00f6chst w\u00fcnschenswert.<\/p>\n

Daher hat Animalfree Research 2009 einen finanziellen Beitrag zu der Entwicklung der \u201eALICE\u201c (Air Liquid Interface Cell Exposure System geleistet. Auch wenn der Betrag nicht sehr hoch war, diente er doch in einer kritischen Situation als (Wieder-) Anschubfinanzierung. Der in vitro Test nutzt humane Epithelzellen um Aerosole oder Substanzen zu pr\u00fcfen. Das Ziel war eine praktikable und breit anwendbare Methode, die Tierversuche in einem breiten Spektrum von Gebieten ersetzen oder reduzieren sollte (Grundlagenforschung, Toxizit\u00e4tstestungen, Medikamentenentwicklung).<\/p>\n

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ALICE\/ VitroCell CLOUD\u00a9 Animalfree Research 2009 einen finanziellen Beitrag zu der Entwicklung der \u201eALICE\u201c (Air Liquid Interface Cell Exposure System geleistet. Das Ziel war eine praktikable und breit anwendbare Methode, die Tierversuche in einem breiten Spektrum von Gebieten ersetzen oder reduzieren sollte. Um die Wirkungen von kurz- oder langfristiger Inhalation bspw. Von Toxinen auf den […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-2038","post","type-post","status-publish","format-standard","hentry","category-completed-projects"],"yoast_head":"\nALICE\/ VitroCell CLOUD\u00a9 - Animalfree Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/animalfree-research.org\/en\/blog\/alice-vitrocell-cloud\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ALICE\/ VitroCell CLOUD\u00a9 - Animalfree Research\" \/>\n<meta property=\"og:description\" content=\"ALICE\/ VitroCell CLOUD\u00a9 Animalfree Research 2009 einen finanziellen Beitrag zu der Entwicklung der \u201eALICE\u201c (Air Liquid Interface Cell Exposure System geleistet. 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